Inhibition of the cytokine response does not protect
against lethal H5N1 influenza infection
Rachelle Salomon *,
"Because proinflammatory cytokines are markedly elevated during H5N1 inflluenza virus infection, the "cytokine storm" is hypothesized to be the main cause of mortality. Here, we demonstrate that mice deficient in the hallmark inflammatory cytokines TNF-, IL-6, or CC chemokine ligand 2 succumb to infection with A/Vietnam/1203/04 (H5N1) virus, as do wild-type mice treated with glucocorticoids for suppression of cytokines. Because cytokine inhibition does not protect against death, therapies that target the virus rather than cytokines may be preferable. "
full free text on PNAS :